{"id":3123,"date":"2025-11-10T17:43:54","date_gmt":"2025-11-10T17:43:54","guid":{"rendered":"https:\/\/ppsg.ch\/?page_id=3123"},"modified":"2025-11-11T01:27:46","modified_gmt":"2025-11-11T01:27:46","slug":"vkorc1-gen-chromosom-16p11-2","status":"publish","type":"page","link":"https:\/\/ppsg.ch\/?page_id=3123","title":{"rendered":"VKORC1-Gen Chromosom 16p11.2"},"content":{"rendered":"<p>Das VKORC1-Gen kodiert f\u00fcr das Enzym Vitamin K Epoxid Reduktase, welches f\u00fcr die Aktivierung von Vitamin K verantwortlich ist. Vitamin K spielt eine zentrale Rolle bei der Blutgerinnung, da es ben\u00f6tigt wird, um wichtige Gerinnungsfaktoren in ihre gerinnungswirksamen Formen zu \u00fcberf\u00fchren. Das Enzym ist das pharmakologische Target der Cumarine, die als Vitamin K-Antagonisten gerinnungshemmend wirken. Der wichtigste Vertreter dieser Gruppe ist Warfarin, welches eine geringe therapeutische Breite aufweist und individuell dosiert werden sollte, da bei der Behandlung h\u00e4ufig unerw\u00fcnschte Blutungen auftreten. Eine Analyse der Variationen des VKORC1-Gens kann helfen, die optimale Dosierung zu finden.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Das VKORC1-Gen kodiert f\u00fcr das Enzym Vitamin K Epoxid Reduktase, welches f\u00fcr die Aktivierung von Vitamin K verantwortlich ist. Vitamin K spielt eine zentrale Rolle bei der Blutgerinnung, da es ben\u00f6tigt wird, um wichtige Gerinnungsfaktoren in ihre gerinnungswirksamen Formen zu \u00fcberf\u00fchren. Das Enzym ist das pharmakologische Target der Cumarine, die als Vitamin K-Antagonisten gerinnungshemmend wirken.<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"class_list":["post-3123","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.6 (Yoast SEO v28.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>VKORC1-Gen Chromosom 16p11.2 -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ppsg.ch\/?page_id=3123\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"VKORC1-Gen Chromosom 16p11.2\" \/>\n<meta property=\"og:description\" content=\"Das VKORC1-Gen kodiert f\u00fcr das Enzym Vitamin K Epoxid Reduktase, welches f\u00fcr die Aktivierung von Vitamin K verantwortlich ist. Vitamin K spielt eine zentrale Rolle bei der Blutgerinnung, da es ben\u00f6tigt wird, um wichtige Gerinnungsfaktoren in ihre gerinnungswirksamen Formen zu \u00fcberf\u00fchren. Das Enzym ist das pharmakologische Target der Cumarine, die als Vitamin K-Antagonisten gerinnungshemmend wirken.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ppsg.ch\/?page_id=3123\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-11T01:27:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ppsg.ch\/wp-content\/uploads\/2023\/04\/Fotolia_139857590_M-Kopie-2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1715\" \/>\n\t<meta property=\"og:image:height\" content=\"1108\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"1\u00a0Minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ppsg.ch\\\/?page_id=3123\",\"url\":\"https:\\\/\\\/ppsg.ch\\\/?page_id=3123\",\"name\":\"VKORC1-Gen Chromosom 16p11.2 -\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ppsg.ch\\\/#website\"},\"datePublished\":\"2025-11-10T17:43:54+00:00\",\"dateModified\":\"2025-11-11T01:27:46+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/ppsg.ch\\\/?page_id=3123\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/ppsg.ch\\\/#website\",\"url\":\"https:\\\/\\\/ppsg.ch\\\/\",\"name\":\"ppsg\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/ppsg.ch\\\/#organization\"},\"alternateName\":\"Psychiatrische Praxis St. Gallen\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/ppsg.ch\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/ppsg.ch\\\/#organization\",\"name\":\"ppsg\",\"alternateName\":\"Psychiatrische Praxis St. Gallen\",\"url\":\"https:\\\/\\\/ppsg.ch\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\\\/\\\/ppsg.ch\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/ppsg.ch\\\/wp-content\\\/uploads\\\/2023\\\/04\\\/400PngdpiLogo.png\",\"contentUrl\":\"https:\\\/\\\/ppsg.ch\\\/wp-content\\\/uploads\\\/2023\\\/04\\\/400PngdpiLogo.png\",\"width\":2672,\"height\":1617,\"caption\":\"ppsg\"},\"image\":{\"@id\":\"https:\\\/\\\/ppsg.ch\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"VKORC1-Gen Chromosom 16p11.2 -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ppsg.ch\/?page_id=3123","og_locale":"de_DE","og_type":"article","og_title":"VKORC1-Gen Chromosom 16p11.2","og_description":"Das VKORC1-Gen kodiert f\u00fcr das Enzym Vitamin K Epoxid Reduktase, welches f\u00fcr die Aktivierung von Vitamin K verantwortlich ist. 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