{"id":3120,"date":"2025-11-10T17:42:00","date_gmt":"2025-11-10T17:42:00","guid":{"rendered":"https:\/\/ppsg.ch\/?page_id=3120"},"modified":"2025-11-11T01:24:41","modified_gmt":"2025-11-11T01:24:41","slug":"tpmt-gen-chromosom-6p22-3","status":"publish","type":"page","link":"https:\/\/ppsg.ch\/?page_id=3120","title":{"rendered":"TPMT-Gen Chromosom 6p22.3"},"content":{"rendered":"

Die Thiopurin S-Methyltransferase \u2013 kodiert durch das TPMT-Gen \u2013 katalysiert die Methylierung von Thiopurinen als Teil der Biotransformation k\u00f6rperfremder Substanzen (Phase II). In TPMT sind normal funktionelle und nicht funktionelle Genkopien bekannt. Aus der Kombination der vorliegenden Genkopien resultieren drei m\u00f6gliche Metabolisierungstypen: Extensive Metabolizer (EM) mit normaler, Intermediate Metabolizer (IM) mit eingeschr\u00e4nkter sowie Poor Metabolizer (PM) mit nahezu nicht vorhandener Enzymaktivit\u00e4t. Bei schlechter TPMT-Aktivit\u00e4t k\u00f6nnen die Substrate nicht ausreichend methyliert und dadurch inaktiviert werden. Hierzu geh\u00f6ren u.a. Azathioprin, Mercaptopurin und Thioguanin.<\/p>\n","protected":false},"excerpt":{"rendered":"

Die Thiopurin S-Methyltransferase \u2013 kodiert durch das TPMT-Gen \u2013 katalysiert die Methylierung von Thiopurinen als Teil der Biotransformation k\u00f6rperfremder Substanzen (Phase II). In TPMT sind normal funktionelle und nicht funktionelle Genkopien bekannt. Aus der Kombination der vorliegenden Genkopien resultieren drei m\u00f6gliche Metabolisierungstypen: Extensive Metabolizer (EM) mit normaler, Intermediate Metabolizer (IM) mit eingeschr\u00e4nkter sowie Poor Metabolizer<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"class_list":["post-3120","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nTPMT-Gen Chromosom 6p22.3 -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ppsg.ch\/?page_id=3120\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"TPMT-Gen Chromosom 6p22.3\" \/>\n<meta property=\"og:description\" content=\"Die Thiopurin S-Methyltransferase \u2013 kodiert durch das TPMT-Gen \u2013 katalysiert die Methylierung von Thiopurinen als Teil der Biotransformation k\u00f6rperfremder Substanzen (Phase II). In TPMT sind normal funktionelle und nicht funktionelle Genkopien bekannt. Aus der Kombination der vorliegenden Genkopien resultieren drei m\u00f6gliche Metabolisierungstypen: Extensive Metabolizer (EM) mit normaler, Intermediate Metabolizer (IM) mit eingeschr\u00e4nkter sowie Poor Metabolizer\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ppsg.ch\/?page_id=3120\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-11T01:24:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ppsg.ch\/wp-content\/uploads\/2023\/04\/Fotolia_139857590_M-Kopie-2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1715\" \/>\n\t<meta property=\"og:image:height\" content=\"1108\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"1\u00a0Minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ppsg.ch\\\/?page_id=3120\",\"url\":\"https:\\\/\\\/ppsg.ch\\\/?page_id=3120\",\"name\":\"TPMT-Gen Chromosom 6p22.3 -\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ppsg.ch\\\/#website\"},\"datePublished\":\"2025-11-10T17:42:00+00:00\",\"dateModified\":\"2025-11-11T01:24:41+00:00\",\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/ppsg.ch\\\/?page_id=3120\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/ppsg.ch\\\/#website\",\"url\":\"https:\\\/\\\/ppsg.ch\\\/\",\"name\":\"ppsg\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/ppsg.ch\\\/#organization\"},\"alternateName\":\"Psychiatrische Praxis St. Gallen\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/ppsg.ch\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/ppsg.ch\\\/#organization\",\"name\":\"ppsg\",\"alternateName\":\"Psychiatrische Praxis St. Gallen\",\"url\":\"https:\\\/\\\/ppsg.ch\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\\\/\\\/ppsg.ch\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/ppsg.ch\\\/wp-content\\\/uploads\\\/2023\\\/04\\\/400PngdpiLogo.png\",\"contentUrl\":\"https:\\\/\\\/ppsg.ch\\\/wp-content\\\/uploads\\\/2023\\\/04\\\/400PngdpiLogo.png\",\"width\":2672,\"height\":1617,\"caption\":\"ppsg\"},\"image\":{\"@id\":\"https:\\\/\\\/ppsg.ch\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"TPMT-Gen Chromosom 6p22.3 -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ppsg.ch\/?page_id=3120","og_locale":"de_DE","og_type":"article","og_title":"TPMT-Gen Chromosom 6p22.3","og_description":"Die Thiopurin S-Methyltransferase \u2013 kodiert durch das TPMT-Gen \u2013 katalysiert die Methylierung von Thiopurinen als Teil der Biotransformation k\u00f6rperfremder Substanzen (Phase II). In TPMT sind normal funktionelle und nicht funktionelle Genkopien bekannt. Aus der Kombination der vorliegenden Genkopien resultieren drei m\u00f6gliche Metabolisierungstypen: Extensive Metabolizer (EM) mit normaler, Intermediate Metabolizer (IM) mit eingeschr\u00e4nkter sowie Poor Metabolizer","og_url":"https:\/\/ppsg.ch\/?page_id=3120","article_modified_time":"2025-11-11T01:24:41+00:00","og_image":[{"width":1715,"height":1108,"url":"https:\/\/ppsg.ch\/wp-content\/uploads\/2023\/04\/Fotolia_139857590_M-Kopie-2.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Gesch\u00e4tzte Lesezeit":"1\u00a0Minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/ppsg.ch\/?page_id=3120","url":"https:\/\/ppsg.ch\/?page_id=3120","name":"TPMT-Gen Chromosom 6p22.3 -","isPartOf":{"@id":"https:\/\/ppsg.ch\/#website"},"datePublished":"2025-11-10T17:42:00+00:00","dateModified":"2025-11-11T01:24:41+00:00","inLanguage":"de","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ppsg.ch\/?page_id=3120"]}]},{"@type":"WebSite","@id":"https:\/\/ppsg.ch\/#website","url":"https:\/\/ppsg.ch\/","name":"ppsg","description":"","publisher":{"@id":"https:\/\/ppsg.ch\/#organization"},"alternateName":"Psychiatrische Praxis St. Gallen","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ppsg.ch\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"de"},{"@type":"Organization","@id":"https:\/\/ppsg.ch\/#organization","name":"ppsg","alternateName":"Psychiatrische Praxis St. Gallen","url":"https:\/\/ppsg.ch\/","logo":{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/ppsg.ch\/#\/schema\/logo\/image\/","url":"https:\/\/ppsg.ch\/wp-content\/uploads\/2023\/04\/400PngdpiLogo.png","contentUrl":"https:\/\/ppsg.ch\/wp-content\/uploads\/2023\/04\/400PngdpiLogo.png","width":2672,"height":1617,"caption":"ppsg"},"image":{"@id":"https:\/\/ppsg.ch\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/ppsg.ch\/index.php?rest_route=\/wp\/v2\/pages\/3120","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ppsg.ch\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ppsg.ch\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ppsg.ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ppsg.ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3120"}],"version-history":[{"count":2,"href":"https:\/\/ppsg.ch\/index.php?rest_route=\/wp\/v2\/pages\/3120\/revisions"}],"predecessor-version":[{"id":3150,"href":"https:\/\/ppsg.ch\/index.php?rest_route=\/wp\/v2\/pages\/3120\/revisions\/3150"}],"wp:attachment":[{"href":"https:\/\/ppsg.ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3120"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}