{"id":3106,"date":"2025-11-10T17:31:56","date_gmt":"2025-11-10T17:31:56","guid":{"rendered":"https:\/\/ppsg.ch\/?page_id=3106"},"modified":"2025-11-11T01:10:13","modified_gmt":"2025-11-11T01:10:13","slug":"mt-rnr1-gen-mitochondriale-dna","status":"publish","type":"page","link":"https:\/\/ppsg.ch\/?page_id=3106","title":{"rendered":"MT-RNR1-Gen (Mitochondriales RNR1-Gen)"},"content":{"rendered":"

Das mitochondriale RNR1-Gen wird von den Nukleotiden 648-1601 kodiert. Das MT-RNR1-Gen kodiert die 12S mitochondriale Ribosomen-RNA (rRNA). \u00a0Aminoglykosid-Antibiotika st\u00f6ren die Proteinsynthese der Bakterien und bewirken hierdurch, dass sich die Bakterien nicht weiter vermehren k\u00f6nnen. Hierzu blockieren die Aminoglykoside einen Teil des Proteinsyntheseapparats, die sog. rRNA. Eine Mutation im MT-RNR1-Gen (rs267606617) hat zur Folge, dass die hierdurch kodierte menschliche rRNA genauso wie die bakterielle von Aminoglykosiden angegriffen wird. Da Aminoglykoside rasch ins Innenohr gelangen und sich in den Haarsinneszellen anreichern, kann es zu starken, z.T. irreversiblen H\u00f6rsch\u00e4digungen kommen.<\/p>\n","protected":false},"excerpt":{"rendered":"

Das mitochondriale RNR1-Gen wird von den Nukleotiden 648-1601 kodiert. Das MT-RNR1-Gen kodiert die 12S mitochondriale Ribosomen-RNA (rRNA). \u00a0Aminoglykosid-Antibiotika st\u00f6ren die Proteinsynthese der Bakterien und bewirken hierdurch, dass sich die Bakterien nicht weiter vermehren k\u00f6nnen. Hierzu blockieren die Aminoglykoside einen Teil des Proteinsyntheseapparats, die sog. rRNA. Eine Mutation im MT-RNR1-Gen (rs267606617) hat zur Folge, dass die<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":71,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"class_list":["post-3106","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nMT-RNR1-Gen (Mitochondriales RNR1-Gen) -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ppsg.ch\/?page_id=3106\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MT-RNR1-Gen (Mitochondriales RNR1-Gen)\" \/>\n<meta property=\"og:description\" content=\"Das mitochondriale RNR1-Gen wird von den Nukleotiden 648-1601 kodiert. Das MT-RNR1-Gen kodiert die 12S mitochondriale Ribosomen-RNA (rRNA). \u00a0Aminoglykosid-Antibiotika st\u00f6ren die Proteinsynthese der Bakterien und bewirken hierdurch, dass sich die Bakterien nicht weiter vermehren k\u00f6nnen. Hierzu blockieren die Aminoglykoside einen Teil des Proteinsyntheseapparats, die sog. rRNA. 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