{"id":3095,"date":"2025-11-10T17:09:01","date_gmt":"2025-11-10T17:09:01","guid":{"rendered":"https:\/\/ppsg.ch\/?page_id=3095"},"modified":"2025-11-10T17:09:01","modified_gmt":"2025-11-10T17:09:01","slug":"dpyd-gen-chromosom-1p22","status":"publish","type":"page","link":"https:\/\/ppsg.ch\/?page_id=3095","title":{"rendered":"DPYD-Gen Chromosom 1p22"},"content":{"rendered":"

Das Phase I-Enzym Dihydropyrimidindehydrogenase (DPYD) ist am Abbau der k\u00f6rpereigenen DNA-Bausteine Thymin und Uracil beteiligt und reguliert somit ihre Verf\u00fcgbarkeit im K\u00f6rper. Einige Zytostatika imitieren die Struktur dieser DNA-Bausteine, um die DNA-Synthese zu blockieren, und werden somit ebenfalls durch das Enzym abgebaut. In DPYD sind normal, vermindert und nicht funktionelle Genkopien bekannt. Aus der Kombination der vorliegenden Genkopien resultieren drei m\u00f6gliche Metabolisierungstypen: Extensive Metabolizer (EM) mit normaler, Intermediate Metabolizer (IM) mit eingeschr\u00e4nkter sowie Poor Metabolizer (PM) mit nahezu nicht vorhandener Enzymaktivit\u00e4t. Schlechte DPYD-Aktivit\u00e4t f\u00fchrt bei Einnahme der dar\u00fcber metabolisierten Zytostatika zu einer massiven \u00dcberdosierung mit schweren, teilweise sogar lebensbedrohlichen Nebenwirkungen.<\/p>\n","protected":false},"excerpt":{"rendered":"

Das Phase I-Enzym Dihydropyrimidindehydrogenase (DPYD) ist am Abbau der k\u00f6rpereigenen DNA-Bausteine Thymin und Uracil beteiligt und reguliert somit ihre Verf\u00fcgbarkeit im K\u00f6rper. Einige Zytostatika imitieren die Struktur dieser DNA-Bausteine, um die DNA-Synthese zu blockieren, und werden somit ebenfalls durch das Enzym abgebaut. In DPYD sind normal, vermindert und nicht funktionelle Genkopien bekannt. Aus der Kombination<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":42,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"class_list":["post-3095","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nDPYD-Gen Chromosom 1p22 -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ppsg.ch\/?page_id=3095\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"DPYD-Gen Chromosom 1p22\" \/>\n<meta property=\"og:description\" content=\"Das Phase I-Enzym Dihydropyrimidindehydrogenase (DPYD) ist am Abbau der k\u00f6rpereigenen DNA-Bausteine Thymin und Uracil beteiligt und reguliert somit ihre Verf\u00fcgbarkeit im K\u00f6rper. Einige Zytostatika imitieren die Struktur dieser DNA-Bausteine, um die DNA-Synthese zu blockieren, und werden somit ebenfalls durch das Enzym abgebaut. In DPYD sind normal, vermindert und nicht funktionelle Genkopien bekannt. 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