{"id":3071,"date":"2025-11-10T16:49:16","date_gmt":"2025-11-10T16:49:16","guid":{"rendered":"https:\/\/ppsg.ch\/?page_id=3071"},"modified":"2025-11-10T16:49:16","modified_gmt":"2025-11-10T16:49:16","slug":"cyp2c9-gen-chromosom-10q24-2","status":"publish","type":"page","link":"https:\/\/ppsg.ch\/?page_id=3071","title":{"rendered":"CYP2C9-Gen Chromosom 10q24"},"content":{"rendered":"

CYP2C9 ist nach CYP3A4 das quantitativ am meisten exprimierte Cytochrom P450 und f\u00fcr die Clearance von 15-20% aller Wirkstoffe verantwortlich, die in Phase I metabolisiert werden. Pharmakogenetisch sind mehrere Varianten mit eingeschr\u00e4nkter Enzymfunktion relevant, die sich auf verschiedene Wirkstoffe auswirken, darunter einige mit geringer therapeutischer Breite wie z.B. Warfarin. In CYP2C9 sind normal, vermindert und nicht funktionelle Genkopien bekannt. Aus der Kombination der vorliegenden Genkopien resultieren drei m\u00f6gliche Metabolisierungstypen: Extensive Metabolizer (EM) mit normaler, Intermediate Metabolizer (IM) mit eingeschr\u00e4nkter sowie Poor Metabolizer (PM) mit nahezu nicht vorhandener Enzymaktivit\u00e4t.<\/p>\n","protected":false},"excerpt":{"rendered":"

CYP2C9 ist nach CYP3A4 das quantitativ am meisten exprimierte Cytochrom P450 und f\u00fcr die Clearance von 15-20% aller Wirkstoffe verantwortlich, die in Phase I metabolisiert werden. Pharmakogenetisch sind mehrere Varianten mit eingeschr\u00e4nkter Enzymfunktion relevant, die sich auf verschiedene Wirkstoffe auswirken, darunter einige mit geringer therapeutischer Breite wie z.B. Warfarin. In CYP2C9 sind normal, vermindert und<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":35,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"class_list":["post-3071","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nCYP2C9-Gen Chromosom 10q24 -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ppsg.ch\/?page_id=3071\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CYP2C9-Gen Chromosom 10q24\" \/>\n<meta property=\"og:description\" content=\"CYP2C9 ist nach CYP3A4 das quantitativ am meisten exprimierte Cytochrom P450 und f\u00fcr die Clearance von 15-20% aller Wirkstoffe verantwortlich, die in Phase I metabolisiert werden. Pharmakogenetisch sind mehrere Varianten mit eingeschr\u00e4nkter Enzymfunktion relevant, die sich auf verschiedene Wirkstoffe auswirken, darunter einige mit geringer therapeutischer Breite wie z.B. Warfarin. 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Pharmakogenetisch sind mehrere Varianten mit eingeschr\u00e4nkter Enzymfunktion relevant, die sich auf verschiedene Wirkstoffe auswirken, darunter einige mit geringer therapeutischer Breite wie z.B. Warfarin. 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